Director, Process Safety and SIF (Serious Injury & Fatality) Prevention

Company: AstraZeneca
Location: Montgomery Village
Posted on: February 18, 2026

Job Description:

As one of the architects of AstraZeneca’s global Process Safety and SIF strategy, you will reshape our global safety culture, influence senior executives, and accelerate our transition to pioneering digital, human?centric, and design?for?safety practices. Your work will not only protect people, it will directly enable AstraZeneca’s ability to deliver medicines safely, sustainably, and at scale. If you want to leave a lasting legacy across a global enterprise, this is your opportunity. About the Role The Director, Process Safety & SIF Prevention is a high?impact global leadership position accountable for designing, governing, and delivering the enterprise-wide strategy to eliminate serious injuries and fatalities across Operations, R&D, and Commercial environments. You will lead a global transformation agenda that sets new standards for risk reduction, competency, technology integration, and safety?critical decision making. This role partners broadly—across senior business leaders, engineering, manufacturing, R&D, and SHE teams—to embed a unified, risk?intelligent operating framework. Scope, Governance & Decision Rights Global Span & Authority Enterprise-wide remit across all AstraZeneca Operations, R&D sites, engineering projects, and commercial environments. Authority to set global Process Safety and SIF standards, expectations, and minimum technical requirements. Strategic decision rights on global policies, frameworks, and risk controls. Reporting Line Reports to the Senior Director, Global SHE (Safety, Health & Environment). Serves as a member of the Global SHE Leadership Team. Team Leadership Direct leadership of a global team of Process Safety and SIF subject matter experts (approx. 6–10 direct reports; 40–60 indirect contributors across regions and sites). Oversight of cross?functional working groups, networks, and communities of practice. Budget Accountability Owns or influences a multi?million?dollar global investment portfolio for Process Safety technology, training, standards development, and capability building. Decision-making input on capital projects and safety?critical expenditures. What You Can Expect at AstraZeneca A purposeful culture where safety is a strategic priority, not a compliance activity Opportunities to influence the organization at the highest levels of the Support to innovate, reimagine, and design future?focused risk?reduction systems Global career growth and exposure across Operations, Science, and Engineering A collaborative environment where bold thinking is encouraged Key Accountabilities Lead the global Process Safety & SIF strategy and deliver a multiyear transformation that proactively eliminates catastrophic risk across the enterprise. Influence senior executives and functional leaders to prioritize high?risk reduction, embed hierarchy?of?controls thinking, and advance human?centric design. Own and enhance the global Process Safety Management framework, ensuring consistent implementation of high?hazard activity controls and world?class standards, competencies, and assurance systems. Deploy digital, analytical, and sensor?based technologies while building internal/external technical networks, developing predictive indicators, and strengthening organizational capability through training and leadership engagement. Serve as the senior technical authority for major incident investigations, Safety?in?Design integration, and global SHE audit support to drive systemic learning and sustained improvement. Minimum Qualifications Bachelor’s degree in engineering, science, or related field, or equivalent senior-level Process Safety experience. 8 years of senior SHE leadership experience with proven global scope and achievement in high?hazard environments. Deep expertise in Process Safety and major hazards legislation, with advanced understanding of PHA, LOPA, Bowtie, and hazardous area classification to lead global technical governance. 10 years leading or overseeing high?risk or high?hazard work programs across multi?site or global operations. Demonstrated capability to influence senior executives and drive enterprise?level transformation. Strong leadership presence with the ability to inspire, motivate, and unify global teams. Proven experience leading global programs, budgets, and cross?functional stakeholders. Willingness to travel internationally. Desired Qualifications Advanced professional certifications (e.g., CSP, CCPS, PE, or equivalent global credentials). Executive?level communication and storytelling skills, with the ability to influence senior leaders on complex risk topics. Experience engaging with regulatory authorities across multiple international jurisdictions. Familiarity with emerging process safety technologies (AI/ML analytics, sensing technologies, digital twins) and Human & Organizational Performance research. Demonstrated experience leading global transformation or safety?culture change programs. Experience integrating Process Safety into Engineering and major capital project design. Proven ability to build global capability frameworks, training programs, and technical competency development. Success navigating and influencing in highly matrixed, multicultural global environments. Pay Transparency/ On-Site Office policy The annual base pay for this position ranges from $175,572- $263,538 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. Thats why we work, on average, a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. At AstraZeneca, we are driven by our commitment to deliver accelerated growth for AstraZeneca and make peoples lives better. We thrive in our often-intense environment by seeking out new challenges and working towards innovative solutions. Here you can build a long-term career with global knowledge opportunities while positively impacting local communities.

Keywords: AstraZeneca, Burke , Director, Process Safety and SIF (Serious Injury & Fatality) Prevention, Human Resources , Montgomery Village, Virginia